Analysis of more than 1,500 blood proteins revealed a class of biomarkers that accurately predicted an individual's risk of developing dementia/Alzheimer's disease 15 years later.

The discovery is a major milestone toward developing precise liquid biopsies to predict the disease, which could help detect Alzheimer's and other forms of dementia at an early stage.

Using blood samples from more than 50,000 adults in the UK Biobank, researchers discovered four proteins closely related to dementia: GFAP, NEFL, GDF15 and LTBP2, as shown in the figure:

The researchers combined these protein biomarkers with factors such as an individual's age, gender, education level, and family history, and used an AI-ML algorithm model to predict the incidence of dementia 15 years before dementia symptoms appear, with an accuracy rate of up to 90%.

The results of this study provide a clinically feasible method for early diagnosis of dementia. The researchers are further verifying whether these specific biomarkers can be used for early screening in healthy people.

Alzheimer's disease has a certain degree of familial inheritance, and in a few cases it can be transmitted; the latest research has shown that it is possible to predict the high risk of the disease early, but unfortunately there is still a lack of effective treatment drugs and methods. Pay attention to details.